HTRA2 and migraine with aura: Additionally, ion channels associated with migraine with aura but also neuropathic pain were abundantly expressed in the nociceptor stage such as SCN1A, SCN2A, SCN3A, SCN9A, KCNA1, HCN2, CLCN3, and KCNA2 but also serotonergic receptors such as HTRA2 and glutamatergic receptors such as GRM5 and GRIN3A, proving suitability of the model to study both diseases (Figure 7B, Table S20, Supporting Information).