Supercluster enrichments for neuropathic pain and migraine with aura associated genes revealed a significant enrichment during the nociceptor stage for migraine with Aura, while for neuropathic pain the largest number of genes were associated with the nociceptor stage as expected, such as ORPM1, CHRNA4, CACNA1B and the metabotropic glutamate receptors GRM5, however no significant enrichment was detected (Figure 7B, contingency table statistics > 0.05; Table S19/S20, Supporting Information). The gene discussed is CACNA1B; the disease is migraine disorder.