For patients with a RASopathy following ACMG reclassification (n = 43), 33 patients had a single pathogenic/likely pathogenic variant (RAF1 n = 5, PTPN11 n = 17, RIT1 n = 6, HRAS n = 4, BRAF n = 1) and 5 had more than one variant [PTPNP11 (P) + MYH7 (VUS), LZRT1 (VUS) + MYH7 (VUS); PTPN11 (P) + MYH7 (LP); LZRT1 (LP) + HRAS (VUS); DSC2 (VUS) + SCN5A (VUS)]. The gene discussed is DSC2; the disease is RASopathy.