Data available concerning Vitronectin are still scarce, but it has been postulated that this adhesive glycoprotein plays a role in the provisional matrix of tumours, promoting cell adhesion and matrix degradation by binding to integrins, plasminogen activator inhibitor-1 (PAI-1) and urokinase plasminogen activator receptor (uPAR) [37]. Here, ART4 is linked to neoplasm.