NRF1 and small cell lung carcinoma: Additional techniques include live-cell reporter strategies to simultaneously monitor mitochondrial biogenesis and morphology using mitochondrial-targeted GFP expression under control of Nrf1 [47] as well as a 2D confocal imaging-based approach using Mitotracker® staining that combines automatic mitochondrial morphology and dynamics analysis with fractal analysis in live small cell lung cancer (SCLC) cells [48].