GBM cells predominantly express 2 different ERβ isoforms (ERβ1 and ERβ5).19 Since ERβ1 and ERβ5 isoforms are regulated by distinct promoters 0N and 0K, respectively, and possess contrasting functions in GBM, we examined whether epigenetic enzyme inhibitors upregulate the expression of both isoforms of ERβ using RT-qPCR. This evidence concerns the gene ESR2 and glioblastoma.