ERβ functions as a tumor suppressor in many cancers and its expression is reduced during cancer progression.25–28 Recent studies have shown that glial tumors express ERβ and this expression decreases during glioma progression.15,25 In this study, we tested the hypothesis that histone-mediated epigenetic changes contribute to alterations in ERβ expression and HDACi may upregulate ERβ expression. The gene discussed is ESR2; the disease is cancer.