A recent study showed that HDAC 1, 2, 3, and 7 are significantly increased in grade III and IV glioma, while HDAC 4, 5, 6, 8, and 11 expressions are decreased in glioma patients.39 Panobinostat and romidepsin mediated increase in ERβ expression which was observed in our study may have been mediated by inhibiting class I HDAC isoforms. Here, ESR2 is linked to central nervous system cancer.