We previously demonstrated that IGFBP‐3 and TGF‐β inhibit growth in epithelial cells by stimulating TβR‐V‐mediated tumor suppressor signaling which involves IRS‐1/2‐dependent activation and cytoplasm‐to‐nucleus translocation of IGFBP‐3‐ or TGF‐β‐stimulated protein phosphatase (PPase), and dephosphorylation of retinoblastoma family proteins in the nucleus, resulting in cell growth arrest.7, 10, 22, 23. The gene discussed is IGFBP3; the disease is neoplasm.