IGFBP‐3R/TMEM219 was identified as a cell death receptor mediating IGFBP‐3‐induced anti‐tumor effects in cancer cells49, 50 and as an autophagy‐activation receptor mediating IGFBP‐3‐activated autophagy in Vero cells.51 The gene discussed is IGFBP3; the disease is neoplasm.