Given their pleotropic effects, neutrophils, NETs, and inflammation have been pathologically linked to tumor growth.22,23 The aims of this study were to determine whether (1) NETs and EETs formation occur in cHL and its association with fibrosis, (2) HRS cells express PAR-2 and show nuclear staining for p-ERK,20 and (3) TF, the clotting initiator,18,19 is expressed in the neoplastic nodes, given the procoagulant properties of ETs. This evidence concerns the gene F2RL1 and neoplasm.