CXCL8 and Autoimmunity: For instance, it has been shown that defective stromal remodeling and NETs in lymphoid tissues favor the transition from autoimmunity to lymphoma.30 Another study determined that stromal cell-derived IL-8 induces NET formation and cooperatively sustains follicular lymphoma B-cell growth.31 In addition, a recent paper reported that diffuse large B-cell lymphoma cells produce IL-8 to stimulate NET formation, which leads to TLR-9 activation in neoplastic cells.