Additionally, miR-103 in HCC exosomes can target and regulate adhesion-related factors (e.g., VE-cadherin [VE-Cad], p120, and ZO-1) in VE cells, destroying the integrity of cell adhesion and promoting invasion and distant metastasis of HCC (Table 1).99 This evidence concerns the gene HNRNPU and hepatocellular carcinoma.