In certain tumor cells, α4β1 is expressed on the cell surface and binds to vascular cell adhesion molecule 1 (VCAM-1) to promote attachment to lymphatic endothelial cells (LECs);114 however, α4β1 is also expressed on LECs in lymph nodes and after activation, plays an important role in capturing VCAM-1-positive tumor cells.115. The gene discussed is VCAM1; the disease is neoplasm.