Macrophage inhibitory factor (MIF) and TGF-β in exosomes derived from pancreatic cancer cells can promote hepatic stellate cells to secrete abundant fibronectin and recruit bone marrow-derived macrophages and neutrophils to transform the liver into a suitable microenvironment for colonization by pancreatic cancer cells.53 The gene discussed is FN1; the disease is familial pancreatic carcinoma.