Nanog expression is significantly higher in exosomes extracted from ascites of high-grade serous ovarian cancer compared with benign peritoneal fluid, and the migration and invasion of ovarian cancer cells decrease when Nanog is knocked out.100, 101, 102 miR-99a-5p levels are significantly increased in ovarian cancer exosomes, and through upregulation of fibronectin and vitronectin, human peritoneal mesothelial cells promote cell invasion.103. Here, NANOG is linked to ovarian carcinoma.