NANOG and ovarian cancer: These exosomes contain proteins unique to ovarian cancer, such as membrane proteins (Alix and TSG101), small GTPases (Rab proteins), annexin, transmembrane proteins (CD9, CD82, CD63, and CD81), HSPs (Hsp90 and Hsc70), antigens (MHC class I and class II), Nanog, and enzymes (phosphate isomerase, peroxidase, aldehyde reductase, and fatty acid synthase).4