The main findings of the study include the following: (1) at the age of 16 weeks, diabetic db/db mice developed hyperglycemia and an increased amount of granulocytes and monocytes in the peripheral blood; (2) BMC of db/db mice produced more GM-CSF, IL-6, and IL-10 than that of wt controls; and (3) compared with no cell injection, injection of BMC isolated from db/db mice accelerated inflammation and acinar cell damage in mice with AP whereas injection of wt BMC did not aggravate disease progression. This evidence concerns the gene IL10 and Hyperglycemia.