Methyltransferase-like 3 (METTL3), as the core of the m6A-related methyltransferase complex, which plays an important role in the progression of various malignant tumors, for instances, upregulation of METTL3 promotes the proliferation of bladder cancer by accelerating the maturation of pri-miR221/222, promotes breast cancer progression by targeting Bcl-2, promotes the chemical and radio resistance of pancreatic cancer cells, and promotes the proliferation of colon cancer cells by inhibiting SOCS2. This evidence concerns the gene METTL3 and colonic neoplasm.