PPP2CA expression was significantly decreased in GC tissue (32 tumor samples vs. 32 normal samples; P = 3.76e − 02; Figure 1(c)), while METTL3 expression was increased significantly in GC tissue (415 tumor samples vs. 35 normal samples; P = 7.32e − 06; Figure 1(d)). The gene discussed is METTL3; the disease is neoplasm.