For example, immunohistochemistry and bioinformatics analysis showed that low expression of PPP2CA is closely related to colon cancer progression and poor prognosis; miR-650 promotes the malignant phenotype of undifferentiated thyroid cancer cells by inhibiting the expression of PPP2CA; upregulating the expression of PPP2CA can reverse the epithelial-mesenchymal transition, proliferation, and distant metastasis of prostate cancer. This evidence concerns the gene PPP2CA and prostate carcinoma.