IL2 and neoplasm: We had proposed10 that in vitro activated autologous anti-tumour T-cells bearing MHC II on their surface, if pulsed with PPD and re-infused in a BCG – primed patient, can activate PPD – specific helper T-cells and the focused secretion of lymphokines like the IL-2 can selectively amplify the anti-tumour T-cell response by their proliferation and activation in a specific manner bypassing the suppression exerted by the anti-idiotypic and suppressor cells (Figure 1).