However, cardiomyocyte-derived miR-217- and miR-208-containing exosomes resulted in cardiac dysfunction and worsened cardiac fibrosis via targeting phosphatase and tensin homolog (PTEN) and dual-specificity tyrosine phosphorylation-regulated kinase 2 (Dyrk2) separately (124, 147). This evidence concerns the gene DYRK2 and fibrosis.