Studies show that lncRNA Novlnc6 is dramatically down-regulated in dilated cardiomyopathy, and Novlnc6 knockdown leads to the expression decreasing of BMP10 and Nkx2.5, which are two important regulators for cardiomyocytes maturation and differentiation (33). Here, NKX2-5 is linked to dilated cardiomyopathy.