Indeed, auranofin induces ferroptosis through inhibition of thioredoxin reductase (TXNRD) activity (Yang et al., 2020) (Figure 5) and has been shown as a successful strategy to induce ferroptosis in small cell lung cancer (SCLC) in combination with BSO-dependent GPX4 inhibition (Bebber et al., 2021). Here, PRDX5 is linked to small cell lung carcinoma.