GPX4 and cancer: Nevertheless, cancer cells with no oncogenic RAS, as HT29 colon cancer cells, are sensitive to GPX4 inhibition, too (Sui et al., 2018), and ectopic expression of NRAS12V, KRAS12V, or HRAS12V protects RMS13 rhabdomyosarcoma cells from Erastin-induced apoptosis (Schott et al., 2015).