For instance, Erastin and RSL3 caused ferroptosis in human tumor cells engineered to express HRASG12V at lower concentrations than wild-type isogenic cells (Yagoda et al., 2007; Yang et al., 2014; Sui et al., 2018), and inhibiting GPX4 re-sensitized KRAS-expressing NSCLC cell lines (A549 and H460) made radioresistant (Pan et al., 2019). This evidence concerns the gene KRAS and neoplasm.