RAF1 and cancer: Even though sorafenib was reported to induce apoptosis and autophagy in cancer cells trough suppression of RAS/RAF signaling pathway (Ullén et al., 2010; Garten et al., 2019), many other studies suggested that sorafenib induces ferroptosis by inhibiting the system xCT independently of the inhibition of RAF pathways (Dixon et al., 2014; Lachaier et al., 2014; Sun et al., 2016) (Figure 5).