LOX and cancer: They showed that 12/15-LOX inhibitors -such as baicalein and PD146176-as well as siRNA-mediated silencing of ALOX15 are able to prevent Erastin- and RSL3-induced ferroptosis in HT-1080, Panc-1 (PDA, KRASG12D) and Calu-1 (NSLC, KRASG12C) human cancer cells (Xie et al., 2016).