Similarly, SIRT-6 expression is upregulated in RAW 264.7 macrophages following dengue virus infection – mechanistically, the shRNA-mediated knockdown of SIRT-6 exacerbates virus-mediated pro-inflammatory cytokine production including IL-6 and TNF-α via a NF-κB p65 subunit mechanism (Li P. et al., 2018). The gene discussed is SIRT6; the disease is dengue disease.