Although SARM-1 is predominantly expressed on neurons and studies discussed earlier in cADPr Synthases ascribe SARM-1 as a driver of neuronal damage, its documented roles in appropriate immune system development and response, alongside the existence of pathogens capable of invading the central nervous system such as Neisseria meningitidis and encephalitis-inducing viruses such as HSV make SARM-1 a potential mediator of neuronal injury and death that arise from such infections. Here, SARM1 is linked to encephalitis.