SMAD2 and familial pancreatic carcinoma: The PPI network and enrichment analysis identified 14 hub genes, TP53, VEGFA, SMAD2, CDKN2A, FOXC, FZD4, LRP5, KDR, FZD5, PAX6, MYCN, NDP, PITX2, and PAX2 that were involved in camera-type eye morphogenesis, pancreatic cancer, the apoptotic process involved in morphogenesis, and the VEGF receptor signaling pathway (Figure 7).