Besides commonly observed aberrations in blood parameters due to systemic infection, such as leukocytosis, neutrophilia, and thrombocytopenia, more characteristic abnormalities in COVID-19 ALI patients were noticed when compared to their non-COVID-19 counterparts, including significantly higher RDW, CRP, and LDH but lower TnT and procalcitonin, whereas D-dimer levels showed similar elevation between the two cohorts. The gene discussed is CRP; the disease is Thrombocytopenia.