The integrin is expressed by mesangial cells, where it sequesters TGF-β, thereby reducing TGF-β signaling. Integrin αvβ8 and its ligand latent TGF-β protect kidney from glomerular dysfunction, endothelial apoptosis, and development of proteinuria, but the role of Integrin αvβ8 in DKD is unknown. The gene discussed is TGFB1; the disease is diabetic kidney disease.