The expression of VEGFA and VEGFR2 is increased in early DKD, but with the loss of podocytes at later stage of DKD, the expression of VEGFA is also significantly decreased. The VEGFA-VEGFR2 signaling contribute to vascular rarefication and renal fibrosis in the development of DKD. The gene discussed is KDR; the disease is renal fibrosis.