TREM1 and fungal infectious disease: Furthermore, BTK-deficient or ibrutinib/acalabrutinib-treated monocytes and macrophages show defects in TLR-mediated phagocytosis of tumor cells as well as TLR9-, TREM-1 and Dectin-1-dependent production of inflammatory cytokines and phagocytosis upon fungal infection (Ormsby et al., 2011; Strijbis et al., 2013; Feng et al., 2015; Bercusson et al., 2018; Fiorcari et al., 2020).