Elevated expression of S100A8/S100A9 caused glucocorticoid resistance in MLL rearranged infant acute lymphoid leukemia (Spijkers-Hagelstein et al., 2012) and negatively associated with BCL2 inhibitor venetoclax in AML (Karjalainen et al., 2019). Here, BCL2 is linked to acute lymphoblastic leukemia.