We studied a cohort of 168 MM patient samples and found that 24% displayed copy number gains of S100 genes, including S100A1, S100A2, S100A3, S100A4, S100A5, S100A6, S100A7, S100A7A, S100A8, S100A9, S100A10, S100A11, S100A12, S100A13, S100A14, S100A16, and TCHLL. Here, S100A6 is linked to Miyoshi myopathy.