S100A4 (also known as a metastasin-1), a metastasis -associated protein and an epithelial to mesenchymal transition (EMT) marker, promotes cell survival and proliferation, angiogenesis, invasion and metastasis, and tumor-promoting inflammation and has been implicated in cancer progression and metastasis (Helfman et al., 2005; Sherbet, 2009). This evidence concerns the gene LYPD5 and cancer.