The mRNA expression profiles showed high expression of S100A4, S100A6, S100A8, S100A9, and S100A12, and low expression of S100A7A, S100A7, S100A14, S100A3, S100A16, S100A2, and S100A5, although all are in the 1q21 region and had similar copy number gains in 116 MM patient samples. Here, S100A4 is linked to Miyoshi myopathy.