Elevated expression of S100A8/S100A9 caused glucocorticoid resistance in MLL rearranged infant acute lymphoid leukemia (Spijkers-Hagelstein et al., 2012) and negatively associated with BCL2 inhibitor venetoclax in AML (Karjalainen et al., 2019). The gene discussed is KMT2A; the disease is acute myeloid leukemia.