Accumulating clinical studies have reported totally 40 cases of patients with BRPF1 monoallelic mutations, with symptoms such as intellectual disability, developmental delay, and epilepsy (Mattioli et al., 2017; Yan et al., 2017, 2020; Baker et al., 2019; Pode-Shakked et al., 2019). This evidence concerns the gene BRPF1 and Intellectual disability.