BRPF1 and Global developmental delay: The cumulative number of patients with BRPF1 mutations has reached 40, and patients were often accompanied with symptoms such as epilepsy, hypotonia, developmental delay, language dysfunction, ptosis, and cerebellar and facial deformities (Mattioli et al., 2017; Yan et al., 2017, 2020; Demeulenaere et al., 2019; Pode-Shakked et al., 2019).