Pnoc is crucially in the neurobiological regulation of stress-coping behavior and fear (Koster et al., 1999); Fgf14 is involved in the regulation of Purkinje cell firing by altering the expression of Nav1.6 channels (Shakkottai et al., 2009); Cacnb2 variation is associated with functional connectivity in the hippocampus in bipolar disorder (Liu et al., 2019); and Sv2b deficiency did not affect glutamatergic or GABAergic transmission (Venkatesan et al., 2012). This evidence concerns the gene PNOC and bipolar disorder.