BRPF1 and Intellectual disability: Bromodomain and PHD finger-containing protein 1 (BRPF1) is an important candidate gene with its monoallelic mutations resulting in intellectual disability (Mattioli et al., 2017; Yan et al., 2017; Demeulenaere et al., 2019; Pode-Shakked et al., 2019), but the exact underlying mechanism remains unclear.