METTL3 and myeloid leukemia: Overexpression of METTL3 inhibits leukemia cell differentiation and increases cell growth; conversely, deletion of METTL3 in human myeloid leukemia cells can induce cell differentiation and promote apoptosis, and delay in vivo leukemia development (Barbieri et al., 2017; Vu et al., 2017; Guirguis et al., 2020).