LDHB and leukemia: Moreover, a recent study found that R-2HG also suppresses glycolysis in leukemia cells by abrogating FTO/m6A/YTHDF2-mediated upregulation of two critical glycolytic genes phosphofructokinase platelet (PFKP) and lactate dehydrogenase B (LDHB) (Qing et al., 2021).