NFE2 and Thrombocytopenia: In conclusion, the present study for the first time predicted the targets and signalling cascades of TMEA action against thrombocytopenia and determined conclusively that the regulation of the PI3K/Akt/mTOR/P70S6K/GATA-1/NF-E2 signalling pathway lies at a nexus of TMEA targeting and megakaryocytic differentiation into proplatelets.