Furthermore, the results of the KEGG analysis revealed that 14 pathways might be involved in TMEA regulatory action in thrombocytopenia, mainly the PI3K-Akt signalling pathway; pathways in glioma, cancer, and chronic myeloid leukaemia; the ErbB signalling pathway; and pathways in prostate cancer and HTLV-I infection. This evidence concerns the gene AKT1 and chronic myelogenous leukemia, BCR-ABL1 positive.