NOTCH1 and central nervous system cancer: In addition to evaluating E-cadherin, the biomarker for the process of EMT (Loh et al., 2019), we also evaluated Notch1 and the wnt signaling because Notch1 (Qian et al., 2020; Zeng et al., 2020) as well as β-catenin (Liu et al., 2016; Zhang et al., 2018) are intricately connected to induction of EMT in various cancers, including gliomas.