In murine models of unilateral ureteral obstruction and folic acid nephropathy-induced renal fibrosis, Tampe et al. (2015, 2017) have demonstrated low-dose hydralazine ameliorates renal fibrosis through induction of Tet3-mediated hydroxymethylation, followed by demethylation of the RASAL1 promoter. The gene discussed is RASAL1; the disease is renal fibrosis.