For instance, in a recent study, Wu et al. (2020) revealed the new AKT2/c-Jun N-terminal kinase (JNK)1/2/c-jun and AKT2/miR-155-5p/DET1/c-Jun signaling pathways that played a role in altering macrophage polarization and regulating periodontitis inflammation and AKT2 promoted M2 polarization of macrophages, suggesting a novel strategy for periodontitis treatment. The gene discussed is MAPK8; the disease is periodontitis.