Chemoattractants [inter alia, hepatocyte growth factor (HGF), TGF-β, and granulocyte-colony stimulating factor (G-CSF)] attract different cell populations to the tumor microenvironment and lead from a decreased pro-inflammatory to an amplified anti-inflammatory state (Hanahan and Weinberg, 2011; De et al., 2016). This evidence concerns the gene CSF3 and neoplasm.