MGMT and neoplasm: However, systemic inhibition of MGMT might lead to increased apoptosis or even the accumulation of mutations in healthy tissue, so that localized application of inhibiting pseudo-substrates or tumor-specific delivery of blocking peptides have been considered as strategies to increase the efficiency of TMZ treatment while not concurrently sensitizing healthy tissue to the alkylating agent (Yu et al., 2020; Wängler et al., 2020, respectively).