HSP90B1 and neoplasm: Although the application of an autologous HSP96-based vaccine (gp96-associated cellular peptides non-covalently bound to HSP96, HSPPC-96) in patients with recurrent glioblastoma are promising, this strategy is limited since the peptide pool is generated from the patient’s tumor and the amount of vaccine depends on the tumor size (Crane et al., 2013).