MGMT and glioblastoma: Alternatively, metronomic application of TMZ might suffice to sensitize relatively resistant glioblastoma cells to this drug, as MGMT is a suicide enzyme that is destroyed upon de-alkylating a base (Karachi et al., 2018; Miyauchi and Tsirka, 2018; Arora and Somasundaram, 2019; Le Rhun et al., 2019; Strobel et al., 2019).