Interestingly, different HD mice strains (R6/1 and R6/2) striatum analysis for the same genomic region showed unchanged level of 5hmC until 12 weeks of age since when the A2AR expression reduces eventually (Villar-Menéndez et al., 2013), which is supporting the fact that changes in DNA methylation pattern is strongly associated and aggravate HD progression. The gene discussed is ADORA2A; the disease is Huntington disease.