PINK1 and Alzheimer disease: Both PINK1 and Parkin play important roles the regulation of mitochondrial function and the elimination of intracellular Aβ aggregates from the AD brain (Khandelwal et al., 2011; Du et al., 2017), and mutations in the PINK1- or Parkin-encoding genes are associated with locomotor deficits in early onset PD and can cause locomotor deficits in Drosophila melanogaster and humans (Pickrell and Youle, 2015).