Protein aggregation is also a feature of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTD); the 43-kDa TAR DNA-binding protein (TDP-43) aggregates in ALS and the microtubule-associated protein tau aggregates in FTD and AD (Ransohoff, 2016). This evidence concerns the gene MAPT and amyotrophic lateral sclerosis.