Both PINK1 and Parkin play important roles the regulation of mitochondrial function and the elimination of intracellular Aβ aggregates from the AD brain (Khandelwal et al., 2011; Du et al., 2017), and mutations in the PINK1- or Parkin-encoding genes are associated with locomotor deficits in early onset PD and can cause locomotor deficits in Drosophila melanogaster and humans (Pickrell and Youle, 2015). Here, PRKN is linked to Alzheimer disease.