Two independent studies identified that DNA methylation at sites close to Ank1, Cdh23, Rhbdf2, and Rpl13 may be linked to AD pathology (De Jager et al., 2014; Lord and Cruchaga, 2014; Lunnon et al., 2014); except for Cdh23, these genes are strongly linked to the AD-associated gene Ptk2b. Advanced ageing is also associated with increased mitochondrial dysfunction and damage, which promotes neurodegeneration via the generation of reactive oxygen species (ROS) and the promotion of neuroinflammation. This evidence concerns the gene CDH23 and Alzheimer disease.