According to risk assessments, ApoE-ε4 homozygotes showed a greater than 50% risk of AD development, whereas ApoE-ε3 and ApoE-ε4 heterozygotes were associated with a 20–30% risk of developing AD in 11% of men and 14% of women overall, irrespective of ApoE allele combination (Philip et al., 2016). This evidence concerns the gene APOE and Alzheimer disease.