Upon the univariate analysis of the predictors of OS, tumor size (P = 0.006), ypTNM stage (P < 0.001), AJCC grade (P = 0.003), UTP6 expression (P < 0.001), the pre-CRT-CA19-9 level (P = 0.012), CD133 expression (P < 0.001), and tumor differentiation (P = 0.013) were independently associated with OS in LARC patients following CRT and TME (Table 3). The gene discussed is PROM1; the disease is neoplasm.