Univariate analysis revealed that tumor size (P = 0.004), ypTNM stage (P < 0.001), AJCC TRG grade (P = 0.013), UTP6 expression (P < 0.001), CD133 expression (P < 0.001), and the pre-CRT-CA19-9 level (P = 0.012) were independently associated with DFS in LARC patients following CRT and TME (Table 2). Here, PROM1 is linked to neoplasm.