The presence of pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) along with the fibroblast-stimulating activity of transforming growth factor beta (TGF-β), make PRP an ideal therapy to promote soft tissue wound healing, which we have verified in multiple studies of augmented ventral hernia repair in rodents (Fernandez-Moure et al., 2015; Van Eps et al., 2016; Fernandez-Moure et al., 2017b; Van Eps et al., 2019). Here, VEGFA is linked to ventral hernia.