T2IR refers to both innate and adaptive arms of the immunity that is developed mainly for the defense against parasitic infection, and characterized by participating cells (e.g. CD4+ TH2 cells, ILC2s, eosinophils, basophils, mast cells, alternatively activated macrophages), antibodies (e.g., the IgE antibody subclass) and cytokines (e.g. IL-4, IL-13, thymic stromal lymphopoietin (TSLP), IL-25 and IL-33) (Wynn, 2015). This evidence concerns the gene TSLP and parasitic infectious disease.