CYLD and melanoma: It has been found that HDAC6 is highly expressed in melanoma, and by knocking down HDAC6 acetylated α-microtubulin increases, acetylated microtubules accumulate, causing CYLD to get around the nucleus, ultimately leading to a reduction in the interaction between CYLD and BCL3, preventing the transcriptional activity of the nuclear factor NF-κB, which in turn affects cell growth and metastasis.