Interestingly, piRNAs from the same region [piR-26681 (DQ596465), piR-26683 (DQ596467), piR-26685 (DQ596469), piR-26686 (DQ596470)] are found to be downregulated in GBM, which may suggest a potential tumor suppressive role of this genomic region. The gene discussed is PIR; the disease is neoplasm.