Two lectins, wheat germ agglutinin (WGA) and Helix pomatia agglutinin (HPA) were taken for lectin histochemistry, the staining of which was decreased in high-grade cervical intraepithelial neoplasia (CIN) relative to adjacent normal tissues in discovery and validation cohorts. The gene discussed is HPSE; the disease is cervical intraepithelial neoplasia.