In HNSCC, RELN positively correlated with abundance of central memory CD8 T cells (Tcm_CD8 T cells; rho = 0.288, p < 0.001, Figure 5E), central memory CD4 T cells (Tcm_CD4 T cells; rho = 0.236, p < 0.001, Figure 5E), natural killer cells (NK cells; rho = 0.357, p < 0.001, Figure 5E), and activated B cells (B cells; rho = 0.313, p < 0.001, Figure 5E). This evidence concerns the gene CD4 and head and neck squamous cell carcinoma.