On the one hand, IGF-I can increase the expression of snail and slug by activating the PI3K/AKT/mTOR signaling pathway, and snail and slug can induce the downregulation of E-cadherin by interacting with the E-box binding site in the E-cadherin promoter and enhance the proliferation of ovarian cancer cells (139). This evidence concerns the gene IGF1 and ovarian cancer.