MCP-1 specifically binds to CCR2 and activates PI3K/AKT/mTOR signaling pathway and its downstream factor hypoxia inducible factor-1α (HIF-1α) and vascular endothelial growth factor -A (VEGF-A), facilitating ovarian cancer cell metastasis to omentum (49). This evidence concerns the gene AKT1 and ovarian cancer.