It can also upregulate the expression of sterol regulatory element binding protein-1 (SREBP1) through the PI3K/AKT signaling pathway, thus promoting the expression of cholesterol acetyltransferase-2 (ACAT2), activating ObR and promoting breast cancer metastasis, proliferation and migration and invasion of breast cancer cells (28). Here, AKT1 is linked to breast carcinoma.