In triple-negative breast cancer, the IGF-I/IGF-IR signaling axis activates focal adhesion kinase (FAK), which is a nonreceptor cytoplasmic protein tyrosine kinase, and then regulates the expression of the transcription cofactor Yap to promote the growth of triple-negative breast cancer (TNBC) cells (141). The gene discussed is PTK2; the disease is triple-negative breast carcinoma.