Therefore, compared with normal weight people, the adiponectin/leptin ratio in obese patients is lower, and the risk of tumors (such as breast cancer, pancreatic cancer, and endometrial cancer) is higher (61, 154, 155).In addition, the study found that the expression level of adiponectin was inversely proportional to that of leptin; that is, when adiponectin expression is increased, the level of leptin expression is decreased accordingly. Here, LEP is linked to familial pancreatic carcinoma.