Studies have demonstrated that oxidative stress increases the levels of proinflammatory cytokines, such as tumor necrosis factor (TNF)-α and interleukin-6 (IL-6), and upregulates inflammatory molecules, such as vascular cell adhesion molecule-1, intercellular adhesion molecule-1, and nuclear factor-kappa B (NF-кB); all of which contribute to tumor growth, migration, and metastasis (8). The gene discussed is TNF; the disease is neoplasm.