Several pathways were upregulated, such as mitogen-activated protein kinase (MAPK) signaling and Janus kinase (JAK)-signal transducer/activator of transcription (JAK/STAT) involved in numerous cellular processes and it is implicated in neurodegenerative disorders, like Alzheimer disease. The gene discussed is WNK2; the disease is early-onset autosomal dominant Alzheimer disease.