In a study of human hepatoma HepG2 cells treated with different concentrations of fumonisinB1 (FB1, a common carcinogen), it was investigated whether there is cross-talk between FB1-induced oxidative stress and m6A. The results showed that FB1 induced intracellular ROS accumulation, and the increase in the m6A level was accompanied by increases in both m6A writers, including METLL3 and METLL14, and readers, including YTHDF1, YTHDF2, YTHDF3, and YTHDC2, and decreases in FTO and ALKBH5. Here, YTHDF2 is linked to hepatocellular carcinoma.