Methyltransferase METTL3 can enhance AK4 expression, increase the level of ROS in breast cancer cells and activate p38 Kinase, and promote the resistance of breast cancer to Tamoxifen, and the role of demethylation ALKBH5 is opposite to that of METTL3 [226]. The gene discussed is METTL3; the disease is breast carcinoma.