CBS and hyperuricemia: Previous studies have reported that 2% taurine in drinking water could significantly decrease blood pressure in L-NAME-induced hypertensive rats [11] and high fructose-induced hypertensive rats [67], upregulate CBS and CSE expression in the aorta of SHRs [15], alleviate kidney damage in hyperuricemia rats [68], and inhibit oxidative stress in the kidneys of diabetic rats [69].