Murine models of lung adenocarcinoma have demonstrated that Tregs may inhibit CD8 T cell-mediated antitumor immunity, with the depletion of Tregs resulting in tumor cell death and elevated levels of granzyme A, granzyme B, perforin, and IFN-γ in infiltrating CD8 T cells at early stages of tumorigenesis [30]. This evidence concerns the gene PRF1 and neoplasm.