We found that age ≥ 66 years (age < 66 years; HR = 1.169; 95% CI,1.112–1.877; P = 0.009) and Foxplow TILs (Foxphigh TILs; HR = 0.711; 95% CI, 0.381–1.101; P = 0.017) were independent prognostic factors for DFS in EGFR-mutant lung adenocarcinoma. Here, EGFR is linked to lung adenocarcinoma.