The pathways mainly regulated by ZJP were pathways in cancer, Chagas disease, hepatitis B, the Toll-like receptor signaling pathway, influenza A, proteoglycans in cancer, the MAPK signaling pathway, HTLV-I infection, the PI3K-Akt signaling pathway, and the prolactin signaling pathway (Table 3). This evidence concerns the gene PIK3CA and Chagas disease.