HIF1A and malignant colon neoplasm: Recent studies have shown that worenine could reverse the Warburg effect and inhibit colon cancer cell growth by negatively regulating HIF-1α [25]; epiberberine could be a novel antitumor candidate against MKN-45-related gastric cancer via targeting the p53-dependent mitochondria-associated pathway [26]; moupinamide had anti-inflammatory potential found in Aswad's study [27].