AKT1 and early-onset autosomal dominant Alzheimer disease: Meanwhile, KEGG pathway annotation statistics of differentially expressed proteins were critically related to pathways in cancer (34 proteins), Alzheimer disease (25 proteins), amyotrophic lateral sclerosis (24 proteins), the PI3K-Akt signaling pathway (23 proteins), and Huntington disease (23 proteins) (Figure 5(b)).