NLRP3 and neoplasm: In addition, repeated intrathecal injections of PDTC also remarkably inhibited BCP-induced NLRP3 activation in the rat spinal cord (∗∗∗p < 0.001 vs. the vehicle control group; n = 4, one-way ANOVA, Figures 5(f) and 5(h)), which demonstrated that tumor inoculation induced NF-κB/NLRP3 inflammatory axis activation in the spinal cord of BCP rats.