In this article, we first studied the expression of different ANXA family members in bladder tumor and normal tissues, and the results showed that the mRNA of ANXA2, ANXA3, ANXA4, ANXA8, and ANXA9 were significantly increased in tumors, while the mRNA of ANXA6, ANXA7, and ANXA11 were significantly decreased in tumor tissues. The gene discussed is ANXA4; the disease is urinary bladder neoplasm.