According to TCGA classification and A Kamoun et al.’s study, urothelial differentiation markers such as FOXA1, GATA3, and KRT20 are highly expressed in luminal-subtype bladder cancer, while FOXA1 and GATA3 are not expressed but KRT5, KRT6, and KRT14 are expressed in basal-subtype bladder cancer. This evidence concerns the gene KRT5 and urinary bladder carcinoma.