The quantitative analysis results were shown in Supplementary Tables 4, 5, results indicated that protein expression level of ANXA9 and ANXA11 was significantly decreased in bladder tumor tissues compared with normal tissues (P = 0.049; P = 0.0014), and the expression level of ANXA1 and ANXA3 in high grade BC were significantly increased than those in low grade bladder cancer (P = 0.0075; P = 0.008). The gene discussed is ANXA1; the disease is urinary bladder cancer.