A stepwise regression model was established comprising gender, age, visceral obesity, ALT, γ-GT, hypertriglyceridemia, hypertension, low HDL-C, hyperglycemia, and combined unfavorable alleles (CYP24A1 rs2296241-A, CYP24A1 rs2248359-T, and CYP27B1 rs4646536-T). The gene discussed is CYP27B1; the disease is hypertensive disorder.