Although no studies have shown a relationship between the polymorphisms of CYP24A1, CYP27B1, and NAFLD, these variants have been extensively investigated in other diseases, such as organ-specific autoimmune endocrine diseases (Ma et al., 2020), CVD (Qian et al., 2020), metabolic diseases (Yu et al., 2020), and multiple cancers (Hibler et al., 2015; Torkko et al., 2020). The gene discussed is CYP27B1; the disease is metabolic disease.