Apart from the above genes, the CDK4 (Ullah Shah et al., 2015), MRE11A (Podralska et al., 2018), BLM (Ding et al., 2009), and TOP3A (Broberg et al., 2009) are shown to be associated with the pathogenesis of breast cancer. The gene discussed is TOP3A; the disease is breast carcinoma.