In this study, the hypoxia risk score was positively correlated with the TIS, the enrichment scores of anti-cancer immunity cycles (such as T cell recruiting and release of cancer cell antigen), and TIICs (such as CD8 T cells and NK cells), which suggested that there was a higher pre-existing anti-cancer immunity in the TME of patients in the high-risk score group (43). The gene discussed is CD8A; the disease is cancer.