We downloaded five Rep-seq datasets containing B cell receptor repertoires from COVID-19 patients from the NCBI SRA database (SRR12190252, SRR12190293, SRR12326739, SRR13518454, SRR13518456) and compared their features to those of 32 references whose Rep-seq datasets were obtained before the COVID-19 pandemic. The gene discussed is PPIB; the disease is COVID-19.