Elevated serum sTNFR is observed in certain infections, cancers, and autoimmune disorders, such as RA, SLE, and SS (101, 102) Recent studies identified an alternatively spliced TNRF2 isoform lacking exons 7 and 8 that encode transmembrane and cytoplasmic domains (DS-TNFR2) (103, 104). The gene discussed is TNFRSF1B; the disease is rheumatoid arthritis.